Acute effects of inspiratory pressure threshold loading upon airway resistance in people with asthma

This is the post-print version of the final paper published in Respiratory Physiology & Neurobiology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2009 Elsevier B.V.Large inspiratory pressures may impart stretch to airway smooth muscle and modify the response to deep inspiration (DI) in asthmatics. Respiratory system resistance (Rrs) was assessed in response to 5 inspiratory manoeuvres using the forced oscillation technique: (a) single unloaded DI; (b) single DI at 25 cmH2O; (c) single DI at 50% maximum inspiratory mouth pressure [MIP]; (d) 30 DIs at 50% MIP; and (e) 30 DIs at 50% MIP with maintenance of normocapnia. Rrs increased after the unloaded DI and the DI at 25 cmH2O but not after a DI at 50% MIP (3.6 ± 1.6 hPa L s−1 vs. 3.6 ± 1.5 hPa L s−1; p = 0.95), 30 DIs at 50% MIP (3.9 ± 1.5 hPa L s−1 vs. 4.2 ± 2.0 hPa L s−1; p = 0.16) or 30 DIs at 50% MIP under normocapnic conditions (3.9 ± 1.5 hPa L s−1 vs. 3.9 ± 1.5 hPa L s−1; p = 0.55). Increases in Rrs in response to DI were attenuated after single and multiple loaded breaths at 50% MIP

A Study of Bentonite as an Additive for Starch Size Press Treatment

The size press has been examined in the past for its application for coating or pre-coating. Bentonite has been found to be a rheology modifier and also has been found to form a film on paper. Bentonite has been found to improve holdout and printing properties as well. In this study, bentonite was applied in small quantities on a pilot machine size press and the paper thus produced was examined for any improvements in coating, physical, and optical properties. Testing showed that bentonite had the greatest effect on porosity and pick strength, in that porosity decreased with increasing bentonite and pick increased with small amounts of bentonite but then fell off with higher levels of bentonite. Generally, it was found that addition of bentonite could be beneficial to some properties at one level of addition while being beneficial to other properties at other levels of addition

X-ray Observations of Distant Optically Selected Cluster

We have measured fluxes or flux limits for 31 of the 79 cluster candidates in the Palomar Distant Cluster Survey (PDCS) using archival ROSAT/PSPC pointed observations. Our X-ray survey reaches a flux limit of $\simeq 3 \times 10^{-14}$ erg s$^{-1}$ cm$^{-2}$ (0.4 - 2.0 keV), which corresponds to luminosities of $L_x\simeq 5 \times 10^{43}$ erg s$^{-1}$ ($H_o$ = 50 km s$^{-1}$ Mpc$^{-1}$, $q_o$ = ${1/2}$), if we assume the PDCS estimated redshifts. Of the 31 cluster candidates, we detect six at a signal-to-noise greater than three. We estimate that $2.9^{+3.3}_{-1.4}$ (90% confidence limits) of these six detections are a result of X-ray emission from objects unrelated to the PDCS cluster candidates. The net surface density of X-ray emitting cluster candidates in our survey, $1.71^{+0.91}_{-2.19}$ clusters deg$^{-2}$, agrees with that of other, X-ray selected, surveys. It is possible, given the large error on our contamination rate, that we have not detected X-ray emission from any of our observed PDCS cluster candidates. We find no statistically significant difference between the X-ray luminosities of PDCS cluster candidates and those of Abell clusters of similar optical richness. This suggests that the PDCS contains objects at high redshift similar to the low redshift clusters in the Abell catalogs. We show that the PDCS cluster candidates are not bright X-ray sources, the average luminosity of the six detected candidates is only $\bar{L_x}=0.9\times10^{44}$ erg s$^{-1}$ (0.4-2.0 keV). This finding is in agreement with previous X-ray studies of high redshift, optically selected, rich clusters of galaxies.Comment: 19 pages, LaTeX with AAS Preprint Macros (v. 4), 3 embedded postscript figures, 3 Seperate Tables using aj_pt4.sty, Accepted by the Astronomical Journal for November 199

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway

Molecular conjugate vectors may be constructed that accomplish high efficiency gene transfer by the receptor-mediated endocytosis pathway. In order to mediate escape from lysosomal degradation, we have incorporated adenoviruses into the functional design of the conjugate. In doing so, however, we have introduced an additional ligand, which can bind to receptors on the cell surface, undermining the potential for cell specific targeting. To overcome this, we have treated the adenovirus with a monoclonal anti-fiber antibody, which renders the virus incapable of binding to its receptor. The result is a multi-functional molecular conjugate vector, which has preserved its binding specificity while at the same time being capable of preventing lysosomal degradation of endosome-internalized conjugate-DNA complexes. This finding indicates that adenoviral binding is not a prerequisite for adenoviral-mediated endosome disruption

Numerical investigations of rock bridge effect on open pit slope stability

Abstract: persistent joint networks in numerical models, and the critical profiles of an open pit mine were analysed. Parallel deterministic networks of infinite and finite lengths, ubiquitous joint network model and Veneziano joint network model were used in order to simulate the rock fractures. Materials were modelled based on the generalised Hoek―Brown and equivalent MohreCoulomb failure criteria. The parallel deterministic infinite and the ubiquitous joint network models produced lower safety factors. The introduction of rock bridges along discontinuity planes in the parallel deterministic network and Veneziano joint network models significantly contributed to the stability and strain distribution, which should be considered in stability analysis of rock mass in open pit by rock slope practitioners. The results show the significance of joints in hard rock behaviour and the joints should be included in order to attain practical and realistic simulations

Recruitment Market Trend Analysis with Sequential Latent Variable Models

Recruitment market analysis provides valuable understanding of industry-specific economic growth and plays an important role for both employers and job seekers. With the rapid development of online recruitment services, massive recruitment data have been accumulated and enable a new paradigm for recruitment market analysis. However, traditional methods for recruitment market analysis largely rely on the knowledge of domain experts and classic statistical models, which are usually too general to model large-scale dynamic recruitment data, and have difficulties to capture the fine-grained market trends. To this end, in this paper, we propose a new research paradigm for recruitment market analysis by leveraging unsupervised learning techniques for automatically discovering recruitment market trends based on large-scale recruitment data. Specifically, we develop a novel sequential latent variable model, named MTLVM, which is designed for capturing the sequential dependencies of corporate recruitment states and is able to automatically learn the latent recruitment topics within a Bayesian generative framework. In particular, to capture the variability of recruitment topics over time, we design hierarchical dirichlet processes for MTLVM. These processes allow to dynamically generate the evolving recruitment topics. Finally, we implement a prototype system to empirically evaluate our approach based on real-world recruitment data in China. Indeed, by visualizing the results from MTLVM, we can successfully reveal many interesting findings, such as the popularity of LBS related jobs reached the peak in the 2nd half of 2014, and decreased in 2015.Comment: 11 pages, 30 figure, SIGKDD 201

A Turn-over in the Galaxy Luminosity Function of the Coma Cluster Core?

Our previous study of the faint end (R$\leq$21.5) of the galaxy luminosity function (GLF) was based on spectroscopic data in a small region near the Coma cluster center. In this previous study Adami et al. (1998) suggested, with moderate statistical significance, that the number of galaxies actually belonging to the cluster was much smaller than expected. This led us to increase our spectroscopic sample. Here, we have improved the statistical significance of the results of the Coma GLF faint end study (R$\leq$22.5) by using a sample of 85 redshifts. This includes both new spectroscopic data and a literature compilation. The relatively small number of faint galaxies belonging to Coma that was suggested by Adami et al. (1998) and Secker et al. (1998) has been confirmed with these new observations. We also confirm that the color-magnitude relation is not well suited for finding the galaxies inside the Coma cluster core, close to the center at magnitudes fainter than R$\sim$19. We show that there is an enhancement in the Coma line of sight of field galaxies compared to classical field counts. This can be explained by the contribution of groups and of a distant $z\sim 0.5$ cluster along the line of sight. The result is that the Coma GLF appears to turn-over or at least to become flat for the faint galaxies. We suggest that this is due to environmental effects.Comment: 8 pages, 6 postscript figures, accepted in A&A, new table 1, updated figure